Benadryl side effects long term - Uses Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes /nose/throat, cough,...

 
Benadryl and Depression. Although there is no direct effect of Benadryl on depression, regular and daily use of Benadryl does result in severe depression in the individual. It is believed to be helpful only for the short term, however, long term use of Benadryl results in certain depressive symptoms in the individual.. John dee

This video examines the question and remark: Benadryl long term side effects! I WISH I had KNOWN! Benadryl is a common OTC medication and is also known as D...Take one to two 50mg tablets at least 30 minutes prior to bedtime. The maximum dose of two tablets works best for sleep. You can take Dramamine with or without food, but make sure you take a dose with a full glass of water 1 2. Swallow tablets whole; don't crush or chew. Plan on taking Dramamine four to six hours prior to waking for the next ...Side effects of antihistamines that make you drowsy can include: sleepiness (drowsiness) and reduced co-ordination, reaction speed and judgement – do not drive or use machinery after taking these antihistamines. dry mouth. blurred vision. difficulty peeing. Side effects of non-drowsy antihistamines can include: headache. Jul 27, 2017 · Take one to two 50mg tablets at least 30 minutes prior to bedtime. The maximum dose of two tablets works best for sleep. You can take Dramamine with or without food, but make sure you take a dose with a full glass of water 1 2. Swallow tablets whole; don't crush or chew. Plan on taking Dramamine four to six hours prior to waking for the next ... Anxiety. Asthma. Car Sickness. Insomnia. Motion sickness. Reactions to Vaccines. Because one of the common side effect of Benadryl in dogs is drowsiness, your vet may use it to alleviate dog anxiety, particularly associated with traveling and motion sickness that may occur during plane rides or car trips.Benadryl and Depression. Although there is no direct effect of Benadryl on depression, regular and daily use of Benadryl does result in severe depression in the individual. It is believed to be helpful only for the short term, however, long term use of Benadryl results in certain depressive symptoms in the individual.hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ...Diphenhydramine is contraindicated in premature infants and neonates, as well as people who are breastfeeding. It is a pregnancy Category B drug. Diphenhydramine has additive effects with alcohol and other CNS depressants. Monoamine oxidase inhibitors prolong and intensify the anticholinergic effect of antihistamines. OverdoseJun 23, 2009 · The most common side effect is drowsiness, causing mild disorientation or dementia. An elderly person may fall asleep during normal activities. This sedating effect can cause unsteadiness. A person over 60 should get up slowly from a sitting or prone position to avoid fainting. If you take an anti-anxiety drug, it is not advisable to use ... Uses Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes /nose/throat, cough,...Oct 3, 2022 · Applies to diphenhydramine: compounding powder, injectable solution, oral capsule, oral disintegrating strip, oral liquid, oral tablet, oral tablet chewable, oral tablet disintegrating. General The most commonly reported side effects included somnolence, dizziness, and incoordination. Diphenhydramine blocks the effects of histamine in your brain and this reduces symptoms. It enters the brain in large quantities and this can make you feel drowsy. Diphenhydramine also blocks the effects of another chemical called acetylcholine. This can help a cough or runny nose but can also cause side effects such as a dry mouth and dry nose.Apr 9, 2020 · Diphenhydramine, brand name Benadryl ®, is one of the oldest and most frequently used over-the-counter medications for children. However, many better options are now widely available, all of which are faster acting, longer lasting, with less side effects. Antihistamines counteract the effect of histamine throughout the body, and treat a range ... 1. McMillan JM, Aitken E, Holroyd-Leduc JM. Management of insomnia and long-term use of sedative- hypnotic drugs in older patients. CMAJ 2013;185:1499–505. [ PMC free article] [ PubMed] [ Google Scholar] 2. Gray SL, Anderson ML, Dublin S, et al. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study.“Atarax (hydroxyzine) and Benadryl (diphenhydramine) were routinely administered in the chemotherapy I received for breast cancer. After 5 months of chemo, I attributed my loss of mental function to a condition I read about called “chemo brain” — and chalked it up as another price paid in side affects for the benefit of staying alive.Diphenhydramine (Benadryl) is a common over-the-counter allergy medication. It’s part of a class of drugs called anticholinergics that research has linked to dementia in older people.January 19, 2022. By Harvard Health Publishing Staff. A report published in JAMA Internal Medicine several years ago highlighted a link between long-term use of anticholinergic medications like Benadryl and dementia. While this study and other observational studies have also found this association, it doesn't prove that these drugs cause dementia.Dec 1, 2022 · Section snippets Sedation. The sedation associated with diphenhydramine is one of the most acknowledged effects of this medication. Indeed, it is frequently used as a medication to treat insomnia. 3 The sedative effect of diphenhydramine is related to its easy penetration of the blood-brain barrier. 4 In the brain, diphenhydramine interferes with H 1 receptors, which causes drowsiness and ... Hives. Swelling and inflammation. Redness. Runny nose and eyes. Coughing. Sneezing. Anaphylactic reaction. One of the side effects of Benadryl is drowsiness, which can help to calm anxious dogs ...hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ...Feb 6, 2023 · Benadryl is an over-the-counter antihistamine that contains the active ingredient diphenhydramine. People often use it to treat allergies. Because it causes drowsiness, some people take it as a ... Jul 27, 2017 · Take one to two 50mg tablets at least 30 minutes prior to bedtime. The maximum dose of two tablets works best for sleep. You can take Dramamine with or without food, but make sure you take a dose with a full glass of water 1 2. Swallow tablets whole; don't crush or chew. Plan on taking Dramamine four to six hours prior to waking for the next ... May 25, 2023 · Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Not able to pass urine or change in how much urine is passed. A very bad skin reaction ( Stevens-Johnson syndrome / toxic epidermal necrolysis) may happen. But it has quite a long list of possible side effects. In fact, the Canadian Society of Allergy and Clinical Immunology has given serious warnings about them, even for people. The organization issued a 2019 position statement about Benadryl. They advised against the drug because of the high risk of side effects and overdose. They said the drug ...Oct 9, 2018 · Many older adults may take sleeping pills because pain, nerve problems or other health issues are keeping them up at night, she says. For these people, a sleeping pill is standing in the way of ... Answer (1 of 2): Here is one long term study: “These drugs are called anticholinergics, among them the first-generation antihistamines that are now marketed as sleep aids.May 17, 2018 · Answer From Eric J. Olson, M.D. It's unlikely you'll become dependent on zolpidem (Ambien). Ambien and similar sleep medications can be effective, and they're much less likely to be habit-forming than some other drugs sometimes prescribed for sleep problems — for example, benzodiazepines, such as alprazolam (Xanax), lorazepam (Ativan) or ... People who take too much Benadryl start to experience many of the medication’s side effects. These can include mild symptoms, such as dry mouth, constipation, and tiredness. Usually, the more Benadryl a person takes, the worse these side effects become. In more severe Benadryl overdose cases, symptoms like seizures, irregular heartbeats, and ...Diphenhydramine or : Benadryl (diphenhydramine) may cause sedation the next day (due to its long half-life), decreased alertness, diminished cognitive function, delirium, ... Read More. Created for people with ongoing healthcare needs but benefits everyone. Learn how we can help. 5k views Reviewed >2 years ago.Diphenhydramine blocks the effects of histamine in your brain and this reduces symptoms. It enters the brain in large quantities and this can make you feel drowsy. Diphenhydramine also blocks the effects of another chemical called acetylcholine. This can help a cough or runny nose but can also cause side effects such as a dry mouth and dry nose. Central side effects. Since these actions are disrupted by sedating antihistamines, these drugs produce sedation, drowsiness, tiredness, lack of concentration, difficulty in learning and memory ...Nov 14, 2022 · A 2017 study revealed that 10% of adults aged 18-45 use OTC sleep aids while 17.5% of people 65 years and older do. Most over-the-counter options are considered safe when used occasionally—as long as the medication is compatible with any medical conditions you have and other medications you take. But when taken night after night, trouble can ... Jul 9, 2015 · Higher dosage or long-term use of common drugs with anticholinergic effects is linked to significantly increased risk of dementia - including Alzheimer’s - says large study. Jan 24, 2018 · Taking an over-the-counter sleep aid with diphenhydramine once in a while is generally not going to cause problems, other than a possible hangover the next day. Older people, however, can get confused when taking diphenhydramine because it also blocks a brain chemical called acetylcholine, which plays a big role in attention and short-term memory. Jun 5, 2019 · The Major Antihistamine Effects of Diphenhydramine Prevents Histamine-Mediated: constriction of respiratory smooth muscle. rapid vasodilation in blood vessels. increased capillary permeability and subsequent edema. sensations of itching, pain, and “flare” formation. increase in heart rate and strength of contraction. hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ...Feb 18, 2010 · One Benadryl per night seems to be enough to keep the ears dry & the resulting nausea at bay. I must admit that I'm not sure this is still even a problem for me. The last time I stopped to see if I still needed it was about 2 years ago. After 3 days, the dizziness/nausea/inner ear issues came back, so I promptly started taking the nightly ... Potential Kidney Risks. Yes, long-term use of Benadryl can put strain on the kidneys, as it can build up in the system. This can cause toxicity and potentially lead to kidney damage. It's important to be aware of the potential side effects of long-term use and to consult a doctor if any symptoms arise.Benadryl helps reduce the effects of natural chemicals in the body called histamines. It is used to treat the side effects of an allergic reaction, including: Benadryl can be taken to relieve the symptoms of hayfever (seasonal allergies) and motion sickness. It can also be taken to induce sleep and treat certain symptoms of Parkinson's disease.Sleep aids: The options. Sleep aids available without a prescription are widely available. Common choices and the potential side effects include: Diphenhydramine (Benadryl). Diphenhydramine is a sedating antihistamine. Side effects might include daytime drowsiness, dry mouth, constipation and urinary retention. Doxylamine (Unisom).Examples of Viagra’s more commonly reported side effects include: headache. flushing (temporary warmth, redness, or deepening of skin color) stuffy nose. indigestion (upset stomach) mild vision ...Apr 8, 2022 · People who take too much Benadryl start to experience many of the medication’s side effects. These can include mild symptoms, such as dry mouth, constipation, and tiredness. Usually, the more Benadryl a person takes, the worse these side effects become. In more severe Benadryl overdose cases, symptoms like seizures, irregular heartbeats, and ... Long term use of some antihistamines may increase your risk of dementia. Diphenhydramine (Benadryl®) blocks the effects of a neurotransmitter called acetylcholine. This neurotransmitter is vital for memory and learning. Diphenhydramine increased the risk of dementia by 54% in one 3,000 patient study followed for seven years. Yes, certain side effects may be possible with long-term use of Benadryl. However, doctors usually don’t recommend Benadryl for long-term use. Instead, they typically advise short-term use of the drug to ease certain symptoms. The drug’s label information* for Benadryl does not specify any long-term side effects for this drug.May 19, 2022 · Yes, certain side effects are possible after using Benadryl long term. For example, long-term use of Benadryl may cause: an increased risk of dementia; withdrawal symptoms after the drug is stopped* However, keep in mind that doctors typically don’t recommend taking Benadryl as a long-term treatment. Apr 11, 2018 · Benadryl is a first-generation antihistamine, meaning it is one of the earlier drugs developed in this category of medications. First-generation antihistamines, like Benadryl, are often noted for their sedative side effects as they have the ability to travel to your brain (i.e. crosses the blood-brain barrier), which is why they can make you ... Addiction and Misuse. Another cause of overdose is an addiction to Diphenhydramine. Patients can become addicted to Benadryl after taking it for an extended period or when it is used for recreational purposes. Side effects of Diphenhydramine overdose often cause long-term damage, which can be fatal to patients ingesting it.Benadryl may cause serious side effects including: pounding heartbeats or fluttering in your chest, painful or difficult urination, little or no urination, confusion, lightheadedness, tightness in your neck or jaw, and. uncontrollable movements of your tongue. Get medical help right away, if you have any of the symptoms listed above.Experts say skip antihistamines. Dana Benson. 713-798-8267. Houston, TX - Jun 28, 2021. Share this article. For people who take an antihistamine such as Benadryl for a cold or allergies, drowsiness is often a welcome side effect. But a Baylor College of Medicine sleep expert cautions against turning to this type of medication as a sleep aid.Diphenhydramine (Benadryl) is a common over-the-counter allergy medication. It’s part of a class of drugs called anticholinergics that research has linked to dementia in older people.Section snippets Sedation. The sedation associated with diphenhydramine is one of the most acknowledged effects of this medication. Indeed, it is frequently used as a medication to treat insomnia. 3 The sedative effect of diphenhydramine is related to its easy penetration of the blood-brain barrier. 4 In the brain, diphenhydramine interferes with H 1 receptors, which causes drowsiness and ...The most common side effect is drowsiness, causing mild disorientation or dementia. An elderly person may fall asleep during normal activities. This sedating effect can cause unsteadiness. A person over 60 should get up slowly from a sitting or prone position to avoid fainting. If you take an anti-anxiety drug, it is not advisable to use ...“The antihistamine diphenhydramine is only approved for management of short-term or temporary sleep difficulties, particularly in those people who have problems falling asleep,” Dr. What are the negative effects of Benadryl? Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of ...Jul 7, 2022 · Advertisement constipation. blurred vision. memory problems and dementia (especially in seniors) anxiety. dependence. What are the side effects of taking Benadryl every night? SIDE EFFECTS: Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacistRead More → “The antihistamine diphenhydramine is only approved for management of short-term or temporary sleep difficulties, particularly in those people who have problems falling asleep,” Dr. What are the negative effects of Benadryl? Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of ...Answer From Eric J. Olson, M.D. It's unlikely you'll become dependent on zolpidem (Ambien). Ambien and similar sleep medications can be effective, and they're much less likely to be habit-forming than some other drugs sometimes prescribed for sleep problems — for example, benzodiazepines, such as alprazolam (Xanax), lorazepam (Ativan) or ...In the drug realm, antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), cetirizine (Zyrtec), and loratadine (Claritin) can help with a stuffy nose are safe for the heart. Nasal sprays deliver a decongestant right where you need it. In theory, this should minimize cardiovascular effects.Benadryl Addiction Side Effects. Despite having numerous benefits in the medical world, Benadryl has its share of negative side effects when abused. Some effects are short term whereas others can last a lifetime. A user can either encounter psychological effects, physical effects, or both. Some of the physical effects to watch out for include ...Diphenhydramine is a type of medicine called an antihistamine. It is used in some allergy and sleep medicines. Overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This article is for information only. DO NOT use it to treat or manage an actual overdose. Jun 5, 2019 · Addiction and Misuse. Another cause of overdose is an addiction to Diphenhydramine. Patients can become addicted to Benadryl after taking it for an extended period or when it is used for recreational purposes. Side effects of Diphenhydramine overdose often cause long-term damage, which can be fatal to patients ingesting it. May 17, 2019 · Diphenhydramine, which is the active ingredient in ZzzQuil, can cause side effects in some people. The most common side effects of diphenhydramine include: drowsiness. dizziness. loss of ... Dear Alice, I've experimented with the abuse of Benadryl on a few occasions now and have been absolutely blown off to another world, I was just curious as to what the side affects, long or short-term, can look like, and what the dangers are of abusing this drug (acetaminophen free).May 8, 2019 · Answer. While Benadryl ( diphenhydramine) can safely be used once in a while as a sleep aid, long-term use is not recommended for multiple reasons. Even the intermittent use of Benadryl for sleep isn't generally recommended if you are elderly (over 65). Studies show that the elderly population doesn't metabolize Benadryl as quickly and are far ... Diphenhydramine (Benadryl) is a common over-the-counter allergy medication. It’s part of a class of drugs called anticholinergics that research has linked to dementia in older people.Dear Alice, I've experimented with the abuse of Benadryl on a few occasions now and have been absolutely blown off to another world, I was just curious as to what the side affects, long or short-term, can look like, and what the dangers are of abusing this drug (acetaminophen free).May 25, 2023 · Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Not able to pass urine or change in how much urine is passed. A very bad skin reaction ( Stevens-Johnson syndrome / toxic epidermal necrolysis) may happen. and readily penetrates the blood-brain-barrier. Thus side effects such as grogginess, drowsiness, and memory loss are common. Diphenhydramine is also used for motion sickness and extrapyramidal symptoms in Parkinson’s disease patients. Potential harm to the brain: Long-term anticholinergic use has been associated with increased The main long-term side effects of Plaquenil are eye-related. ... To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine ...Dec 1, 2022 · Section snippets Sedation. The sedation associated with diphenhydramine is one of the most acknowledged effects of this medication. Indeed, it is frequently used as a medication to treat insomnia. 3 The sedative effect of diphenhydramine is related to its easy penetration of the blood-brain barrier. 4 In the brain, diphenhydramine interferes with H 1 receptors, which causes drowsiness and ... Jun 23, 2009 · The most common side effect is drowsiness, causing mild disorientation or dementia. An elderly person may fall asleep during normal activities. This sedating effect can cause unsteadiness. A person over 60 should get up slowly from a sitting or prone position to avoid fainting. If you take an anti-anxiety drug, it is not advisable to use ... Diphenhydramine is a type of medicine called an antihistamine. It is used in some allergy and sleep medicines. Overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This article is for information only. DO NOT use it to treat or manage an actual overdose.The short answer seems to be yes. While occasionally taking a Benadryl for sleep probably won’t lead to significant weight gain, chronic use of antihistamines can interfere with weight loss efforts. If you need an antihistamine for frequent allergy symptoms, however, the best choice is Claritin because it does not cross into the brain and has ...Apr 8, 2022 · People who take too much Benadryl start to experience many of the medication’s side effects. These can include mild symptoms, such as dry mouth, constipation, and tiredness. Usually, the more Benadryl a person takes, the worse these side effects become. In more severe Benadryl overdose cases, symptoms like seizures, irregular heartbeats, and ... General The most commonly reported side effects included somnolence, dizziness, and incoordination. [ Ref] Nervous system Common (1% to 10%): Sedation/somnolence/sleepiness, drowsiness, unsteadiness, dizziness, headache, attention disturbance Rare (0.01% to 0.1%): Extrapyramidal effects, tremor, convulsionsDizziness Nausea or vomiting Loss of appetite Constipation Increased chest congestion Headache Excitability (especially in children) Nervousness Benadryl can impair mental and motor functioning, as well as your performance at work or school. It can also impair a person’s ability to operate a motor vehicle or other potentially dangerous equipment.Besides having side effects including drowsiness, confusion, and urinary retention, a new study shows that frequent, long-term use of older antihistamines are associated with an increased risk of ...Besides having side effects including drowsiness, confusion, and urinary retention, a new study shows that frequent, long-term use of older antihistamines are associated with an increased risk of ...

Jun 23, 2009 · The most common side effect is drowsiness, causing mild disorientation or dementia. An elderly person may fall asleep during normal activities. This sedating effect can cause unsteadiness. A person over 60 should get up slowly from a sitting or prone position to avoid fainting. If you take an anti-anxiety drug, it is not advisable to use ... . 40 ideas for design off center dining room light.htm

benadryl side effects long term

May 8, 2019 · Answer. While Benadryl ( diphenhydramine) can safely be used once in a while as a sleep aid, long-term use is not recommended for multiple reasons. Even the intermittent use of Benadryl for sleep isn't generally recommended if you are elderly (over 65). Studies show that the elderly population doesn't metabolize Benadryl as quickly and are far ... Aug 1, 2023 · skin rash. swollen joints. stomach discomfort, upset or pain. tender swollen glands in neck. tremor. unusual excitement, nervousness, restlessness, or irritability. vomiting. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Dizziness. Feeling nervous and excitable. Not able to sleep. Feeling sleepy. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https ...Apr 8, 2022 · People who take too much Benadryl start to experience many of the medication’s side effects. These can include mild symptoms, such as dry mouth, constipation, and tiredness. Usually, the more Benadryl a person takes, the worse these side effects become. In more severe Benadryl overdose cases, symptoms like seizures, irregular heartbeats, and ... May 25, 2023 · Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Not able to pass urine or change in how much urine is passed. A very bad skin reaction ( Stevens-Johnson syndrome / toxic epidermal necrolysis) may happen. Examples of Viagra’s more commonly reported side effects include: headache. flushing (temporary warmth, redness, or deepening of skin color) stuffy nose. indigestion (upset stomach) mild vision ...Long-term use of Benadryl can also lead to constipation and confusion. Interactions. Benadryl containing diphenhydramine can interact with alcohol as both are central nervous system (CNS) depressants. Side effects such as drowsiness and dizziness may be enhanced when taking alcohol with diphenhydramine. Apr 8, 2022 · People who take too much Benadryl start to experience many of the medication’s side effects. These can include mild symptoms, such as dry mouth, constipation, and tiredness. Usually, the more Benadryl a person takes, the worse these side effects become. In more severe Benadryl overdose cases, symptoms like seizures, irregular heartbeats, and ... Oct 3, 2022 · Applies to diphenhydramine: oral capsules and tablets, parenteral injection. Side effects include: Sedation, sleepiness, dizziness, disturbed coordination, epigastric distress, thickening of bronchial secretions. Jun 15, 2016 · IV administration of 50 mg of DPH resulted in immediate improvement of tremor, rigidity, tachycardia, and eye versions. The patient was started on oral DPH 50 mg 4 times a day and the dose was reduced by 25% every 3 days. Oral clonidine 0.1 mg 3 times a day and a weekly 0.1 mg transdermal patch was added to mitigate sympathetic side effects. Benadryl dosage for dogs. The correct dosage of diphenhydramine for dogs depends on their weight. A small dog will need much less than a big dog to receive the same positive effects. According to ...feeling of warmth, redness of the face, neck, arms and occasionally, upper chest. large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. shortness of breath, difficult or labored breathing. Some side effects may occur that usually do not need medical attention.Section snippets Sedation. The sedation associated with diphenhydramine is one of the most acknowledged effects of this medication. Indeed, it is frequently used as a medication to treat insomnia. 3 The sedative effect of diphenhydramine is related to its easy penetration of the blood-brain barrier. 4 In the brain, diphenhydramine interferes with H 1 receptors, which causes drowsiness and ...“The antihistamine diphenhydramine is only approved for management of short-term or temporary sleep difficulties, particularly in those people who have problems falling asleep,” Dr. What are the negative effects of Benadryl? Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of ...A 2017 study revealed that 10% of adults aged 18-45 use OTC sleep aids while 17.5% of people 65 years and older do. Most over-the-counter options are considered safe when used occasionally—as long as the medication is compatible with any medical conditions you have and other medications you take. But when taken night after night, trouble can ....

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